Search on: PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE 
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Descriptor English:   Phosphatidylinositol Diacylglycerol-Lyase 
Descriptor Spanish:   Fosfatidilinositol Diacilglicerol-Liasa 
Descriptor Portuguese:   Fosfatidilinositol Diacilglicerol-Liase 
Synonyms English:   1-Phosphatidylinositol Phosphodiesterase  
Tree Number:   D08.811.277.352.640.700.700.500
D08.811.520.650.800
Definition English:   A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction. 
Indexing Annotation English:   note X refs: TYPE C PHOSPHOLIPASES is also available
History Note English:   2004; use PHOSPHOTIDYLINOSITOL DIACYLGLYCEROL-LYASE (NM) 1980-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   38148 
Unique Identifier:   D043265 

Occurrence in VHL:
 

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